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Angiopoietin-2 may contribute to multi-organ dysfunction and death in sepsis

OBJECTIVE: In sepsis, quiescent blood vessels become leaky and inflamed by mechanisms that are incompletely understood. We hypothesized that Angiopoietin-2 (Angpt-2), a partial antagonist of the endothelium-stabilizing receptor Tie-2 secreted by endothelium, contributes to adverse outcomes in this d...

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Autori principali: David, Sascha, Mukherjee, Aditi, Ghosh, Chandra C., Yano, Midori, Khankin, Eliyahu V., Wenger, Julia B., Karumanchi, S. Ananth, Shapiro, Nathan I., Parikh, Samir M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705559/
https://ncbi.nlm.nih.gov/pubmed/22890252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e31825fdc31
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