Mesenchymal Stromal Cells Engineered to Produce IGF-I by Recombinant Adenovirus Ameliorate Liver Fibrosis in Mice

Liver cirrhosis involves chronic wound healing and fibrotic processes. Mesenchymal stromal cells (MSCs) are multipotent adult progenitor cells that are used as vehicles of therapeutic genes. Insulin growth factor like-I (IGF-I) was shown to counteract liver fibrosis. We aimed at analyzing the effect...

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Detalles Bibliográficos
Publicado en:Stem Cells Dev
Autores principales: Fiore, Esteban J., Bayo, Juan M., Garcia, Mariana G., Malvicini, Mariana, Lloyd, Rodrigo, Piccioni, Flavia, Rizzo, Manglio, Peixoto, Estanislao, Sola, M. Beatriz, Atorrasagasti, Catalina, Alaniz, Laura, Camilletti, María A., Enguita, Mónica, Prieto, Jesús, Aquino, Jorge B., Mazzolini, Guillermo
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Original Research Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356192/
https://ncbi.nlm.nih.gov/pubmed/25315017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0174
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