Tumor Microenvironment Remodeling by 4-Methylumbelliferone Boosts the Antitumor Effect of Combined Immunotherapy in Murine Colorectal Carcinoma

We have previously demonstrated that a low dose of cyclophosphamide (Cy) combined with gene therapy of interleukin-12 (AdIL-12) has a synergistic, although limited, antitumoral effect in mice with colorectal carcinoma. The main mechanism involved in the efficacy of Cy+AdIL-12 was the induction of a...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Malvicini, Mariana, Fiore, Esteban, Ghiaccio, Valentina, Piccioni, Flavia, Rizzo, Miguel, Olmedo Bonadeo, Lucila, García, Mariana, Rodríguez, Marcelo, Bayo, Juan, Peixoto, Estanislao, Atorrasagasti, Catalina, Alaniz, Laura, Aquino, Jorge, Matar, Pablo, Mazzolini, Guillermo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817882/
https://ncbi.nlm.nih.gov/pubmed/26105158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.112
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