Mesenchymal Stromal Cells Engineered to Produce IGF-I by Recombinant Adenovirus Ameliorate Liver Fibrosis in Mice

Liver cirrhosis involves chronic wound healing and fibrotic processes. Mesenchymal stromal cells (MSCs) are multipotent adult progenitor cells that are used as vehicles of therapeutic genes. Insulin growth factor like-I (IGF-I) was shown to counteract liver fibrosis. We aimed at analyzing the effect...

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Detalhes bibliográficos
Publicado no:Stem Cells Dev
Main Authors: Fiore, Esteban J., Bayo, Juan M., Garcia, Mariana G., Malvicini, Mariana, Lloyd, Rodrigo, Piccioni, Flavia, Rizzo, Manglio, Peixoto, Estanislao, Sola, M. Beatriz, Atorrasagasti, Catalina, Alaniz, Laura, Camilletti, María A., Enguita, Mónica, Prieto, Jesús, Aquino, Jorge B., Mazzolini, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2015
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356192/
https://ncbi.nlm.nih.gov/pubmed/25315017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2014.0174
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