Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells

BACKGROUND: Cirrhosis is a major health problem worldwide and new therapies are needed. Hepatic macrophages (hMø) have a pivotal role in liver fibrosis, being able to act in both its promotion and its resolution. It is well-known that mesenchymal stromal cells (MSCs) can modulate the immune/inflamma...

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Udgivet i:Stem Cell Res Ther
Main Authors: Fiore, Esteban, Malvicini, Mariana, Bayo, Juan, Peixoto, Estanislao, Atorrasagasti, Catalina, Sierra, Romina, Rodríguez, Marcelo, Gómez Bustillo, Sofia, García, Mariana G., Aquino, Jorge B., Mazzolini, Guillermo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5120504/
https://ncbi.nlm.nih.gov/pubmed/27876093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0424-y
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