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A monomer-trimer model supports intermittent glucagon fibril growth

We investigate in vitro fibrillation kinetics of the hormone peptide glucagon at various concentrations using confocal microscopy and determine the glucagon fibril persistence length 60μm. At all concentrations we observe that periods of individual fibril growth are interrupted by periods of stasis....

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Košmrlj, Andrej, Cordsen, Pia, Kyrsting, Anders, Otzen, Daniel E., Oddershede, Lene B., Jensen, Mogens H.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355668/
https://ncbi.nlm.nih.gov/pubmed/25758791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09005
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