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A monomer-trimer model supports intermittent glucagon fibril growth

We investigate in vitro fibrillation kinetics of the hormone peptide glucagon at various concentrations using confocal microscopy and determine the glucagon fibril persistence length 60μm. At all concentrations we observe that periods of individual fibril growth are interrupted by periods of stasis....

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Publicado en:Sci Rep
Autores principales: Košmrlj, Andrej, Cordsen, Pia, Kyrsting, Anders, Otzen, Daniel E., Oddershede, Lene B., Jensen, Mogens H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355668/
https://ncbi.nlm.nih.gov/pubmed/25758791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09005
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