Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumour growth

Gastrointestinal stromal tumour (GIST), originating from the interstitial cells of Cajal (ICCs), is characterized by frequent activating mutations of the KIT receptor tyrosine kinase. Despite the clinical success of imatinib that targets KIT, most advanced GIST patients develop resistance and eventu...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cancer Discov
मुख्य लेखकों: Ran, Leili, Sirota, Inna, Cao, Zhen, Murphy, Devan, Chen, Yuedan, Shukla, Shipra, Xie, Yuanyuan, Kaufmann, Michael C., Gao, Dong, Zhu, Sinan, Rossi, Ferdinando, Wongvipat, John, Taguchi, Takahiro, Tap, William D., Mellinghoff, Ingo K., Besmer, Peter, Antonescu, Cristina R., Chen, Yu, Chi, Ping
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355391/
https://ncbi.nlm.nih.gov/pubmed/25572173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0985
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