Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumour growth

Gastrointestinal stromal tumour (GIST), originating from the interstitial cells of Cajal (ICCs), is characterized by frequent activating mutations of the KIT receptor tyrosine kinase. Despite the clinical success of imatinib that targets KIT, most advanced GIST patients develop resistance and eventu...

詳細記述

保存先:
書誌詳細
出版年:Cancer Discov
主要な著者: Ran, Leili, Sirota, Inna, Cao, Zhen, Murphy, Devan, Chen, Yuedan, Shukla, Shipra, Xie, Yuanyuan, Kaufmann, Michael C., Gao, Dong, Zhu, Sinan, Rossi, Ferdinando, Wongvipat, John, Taguchi, Takahiro, Tap, William D., Mellinghoff, Ingo K., Besmer, Peter, Antonescu, Cristina R., Chen, Yu, Chi, Ping
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355391/
https://ncbi.nlm.nih.gov/pubmed/25572173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0985
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