Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumour growth

Gastrointestinal stromal tumour (GIST), originating from the interstitial cells of Cajal (ICCs), is characterized by frequent activating mutations of the KIT receptor tyrosine kinase. Despite the clinical success of imatinib that targets KIT, most advanced GIST patients develop resistance and eventu...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cancer Discov
Asıl Yazarlar: Ran, Leili, Sirota, Inna, Cao, Zhen, Murphy, Devan, Chen, Yuedan, Shukla, Shipra, Xie, Yuanyuan, Kaufmann, Michael C., Gao, Dong, Zhu, Sinan, Rossi, Ferdinando, Wongvipat, John, Taguchi, Takahiro, Tap, William D., Mellinghoff, Ingo K., Besmer, Peter, Antonescu, Cristina R., Chen, Yu, Chi, Ping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355391/
https://ncbi.nlm.nih.gov/pubmed/25572173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0985
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller