Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumour growth

Gastrointestinal stromal tumour (GIST), originating from the interstitial cells of Cajal (ICCs), is characterized by frequent activating mutations of the KIT receptor tyrosine kinase. Despite the clinical success of imatinib that targets KIT, most advanced GIST patients develop resistance and eventu...

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Publicado no:Cancer Discov
Main Authors: Ran, Leili, Sirota, Inna, Cao, Zhen, Murphy, Devan, Chen, Yuedan, Shukla, Shipra, Xie, Yuanyuan, Kaufmann, Michael C., Gao, Dong, Zhu, Sinan, Rossi, Ferdinando, Wongvipat, John, Taguchi, Takahiro, Tap, William D., Mellinghoff, Ingo K., Besmer, Peter, Antonescu, Cristina R., Chen, Yu, Chi, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355391/
https://ncbi.nlm.nih.gov/pubmed/25572173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0985
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