ETV1 is a lineage-specific survival factor in GIST and cooperates with KIT in oncogenesis

Gastrointestinal stromal tumour (GIST) is the most common human sarcoma and is primarily defined by activating mutations in the KIT or PDGFRA receptor tyrosine kinases1,2. KIT is highly expressed in interstitial cells of Cajal (ICCs)—the presumed cell of origin for GIST—as well as in hematopoietic s...

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Autors principals: Chi, Ping, Chen, Yu, Zhang, Lei, Guo, Xingyi, Wongvipat, John, Shamu, Tambudzai, Fletcher, Jonathan A., Dewell, Scott, Maki, Robert G., Zheng, Deyou, Antonescu, Cristina R., Allis, C. David, Sawyers, Charles L.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955195/
https://ncbi.nlm.nih.gov/pubmed/20927104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09409
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