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Synonymous Codon Usage Affects the Expression of Wild Type and F508del CFTR
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel composed of 1480 amino acids. The major mutation responsible for cystic fibrosis results in loss of amino acid residue, F508, (F508del). Loss of F508 in CFTR alters the folding pathway resulting in endoplasmic reticul...
Enregistré dans:
| Publié dans: | J Mol Biol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4355305/ https://ncbi.nlm.nih.gov/pubmed/25676312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.02.003 |
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