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Sirtuin inhibitor sirtinol is an intracellular iron chelator
Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the h...
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| Publicado no: | Chem Commun (Camb) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4355247/ https://ncbi.nlm.nih.gov/pubmed/25715179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc00829h |
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