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Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators

Iron scavengers (chelators) offer therapeutic opportunities in anticancer drug design by targeting the increased demand for iron in cancer cells as compared to normal cells. Prochelation approaches are expected to avoid systemic iron depletion as chelators are liberated under specific intracellular...

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Detalhes bibliográficos
Main Authors: Akam, Eman A., Chang, Tsuhen M., Astashkin, Andrei V., Tomat, Elisa
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188698/
https://ncbi.nlm.nih.gov/pubmed/25100578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4mt00153b
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