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Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators

Iron scavengers (chelators) offer therapeutic opportunities in anticancer drug design by targeting the increased demand for iron in cancer cells as compared to normal cells. Prochelation approaches are expected to avoid systemic iron depletion as chelators are liberated under specific intracellular...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Akam, Eman A., Chang, Tsuhen M., Astashkin, Andrei V., Tomat, Elisa
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188698/
https://ncbi.nlm.nih.gov/pubmed/25100578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4mt00153b
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