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Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelators

Iron scavengers (chelators) offer therapeutic opportunities in anticancer drug design by targeting the increased demand for iron in cancer cells as compared to normal cells. Prochelation approaches are expected to avoid systemic iron depletion as chelators are liberated under specific intracellular...

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Detalles Bibliográficos
Autores principales: Akam, Eman A., Chang, Tsuhen M., Astashkin, Andrei V., Tomat, Elisa
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188698/
https://ncbi.nlm.nih.gov/pubmed/25100578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4mt00153b
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