Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring

BACKGROUND: The HHIP gene, encoding Hedgehog interacting protein, has been implicated in chronic obstructive pulmonary disease (COPD) by genome-wide association studies (GWAS), and our subsequent studies identified a functional upstream genetic variant that decreased HHIP transcription. However, lit...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Lao, Taotao, Glass, Kimberly, Qiu, Weiliang, Polverino, Francesca, Gupta, Kushagra, Morrow, Jarrett, Mancini, John Dominic, Vuong, Linh, Perrella, Mark A, Hersh, Craig P, Owen, Caroline A, Quackenbush, John, Yuan, Guo-Cheng, Silverman, Edwin K, Zhou, Xiaobo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355149/
https://ncbi.nlm.nih.gov/pubmed/25763110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0137-3
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