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Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin

Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene that result in loss of the dystrophin–glycoprotein complex, a laminin receptor that connects the myofiber to its surrounding extracellular matrix. Utrophin, a dystrophin ortholog that is normally localized to the neuromu...

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Bibliografiske detaljer
Udgivet i:Hum Mol Genet
Main Authors: Marshall, Jamie L., Oh, Jennifer, Chou, Eric, Lee, Joy A., Holmberg, Johan, Burkin, Dean J., Crosbie-Watson, Rachelle H.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355028/
https://ncbi.nlm.nih.gov/pubmed/25504048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu615
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