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Drugging the undruggable Ras: mission possible?
Despite more than three decades of intensive effort, no effective pharmacologic inhibitors of the Ras oncoproteins have reached the clinic, prompting the widely held perception that Ras proteins are “undruggable”. However, there is renewed hope that this is not the case. In this review, we summarize...
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| Udgivet i: | Nat Rev Drug Discov |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4355017/ https://ncbi.nlm.nih.gov/pubmed/25323927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd4389 |
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