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Drugging the undruggable Ras: mission possible?

Despite more than three decades of intensive effort, no effective pharmacologic inhibitors of the Ras oncoproteins have reached the clinic, prompting the widely held perception that Ras proteins are “undruggable”. However, there is renewed hope that this is not the case. In this review, we summarize...

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Detalhes bibliográficos
Publicado no:Nat Rev Drug Discov
Main Authors: Cox, Adrienne D., Fesik, Stephen W., Kimmelman, Alec C., Luo, Ji, Der, Channing J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355017/
https://ncbi.nlm.nih.gov/pubmed/25323927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd4389
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