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Identification of a Promising Drug Candidate for the Treatment of Type 2 Diabetes Based on a P2Y(1) Receptor Agonist
[Image: see text] The activation by ettracellular nucleotides of pancreatic P2Y receptors, particularly, the P2Y(1)R subtype, increases insulin secretion. Therefure, we developed analogues of the P2Y(1)R receptor agonist 2 MeS ADP, as potential antidiabetic drugs. Analogue 3A was found to be a poten...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4354947/ https://ncbi.nlm.nih.gov/pubmed/22873688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3006355 |
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