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Boranophosphate Isoster Controls P2Y-Receptor Subtype Selectivity and Metabolic Stability of Dinucleoside Polyphosphate Analogues
Dinucleoside polyphosphates, Np(n)N′, exert their physiological effects via P2 receptors (P2Rs). Np(n)N′ are attractive drug candidates as they offer better stability and specificity compared to nucleotides, the most common P2R ligands. To further improve the agonist properties of Np(n)N′, we synthe...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4358768/ https://ncbi.nlm.nih.gov/pubmed/22107038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2013198 |
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