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Dinucleoside polyphosphates act as 5′-RNA caps in bacteria

It has been more than 50 years since the discovery of dinucleoside polyphosphates (Np(n)Ns) and yet their roles and mechanisms of action remain unclear. Here, we show that both methylated and non-methylated Np(n)Ns serve as RNA caps in Escherichia coli. Np(n)Ns are excellent substrates for T7 and E....

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hudeček, Oldřich, Benoni, Roberto, Reyes-Gutierrez, Paul E., Culka, Martin, Šanderová, Hana, Hubálek, Martin, Rulíšek, Lubomír, Cvačka, Josef, Krásný, Libor, Cahová, Hana
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044304/
https://ncbi.nlm.nih.gov/pubmed/32103016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14896-8
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