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Identification of hydrolytically stable and selective P2Y(1) receptor agonists

P2Y nucleotide receptors (P2YRs) are attractive pharmaceutical targets. Most P2YR agonists proposed as drugs consist of a nucleotide scaffold, but their use is limited due to their chemical and enzymatic instabilities. To identify drug candidates, we developed non-hydrolyzable P2YR agonists. We synt...

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Bibliografiske detaljer
Udgivet i:Eur J Med Chem
Main Authors: Eliahu, Shay E., Camden, Jean, Lecka, Joanna, Weisman, Gary A., Sévigny, Jean, Gélinas, Sylvie, Fischer, Bilha
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354951/
https://ncbi.nlm.nih.gov/pubmed/18760862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2008.07.015
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