LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

AIMS/HYPOTHESIS: Glucagon release from pancreatic alpha cells is required for normal glucose homoeostasis and is dysregulated in both Type 1 and Type 2 diabetes. The tumour suppressor LKB1 (STK11) and the downstream kinase AMP-activated protein kinase (AMPK), modulate cellular metabolism and growth,...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Sun, Gao, da Silva Xavier, Gabriela, Gorman, Tracy, Priest, Claire, Solomou, Antonia, Hodson, David J., Foretz, Marc, Viollet, Benoit, Herrera, Pedro-Luis, Parker, Helen, Reimann, Frank, Gribble, Fiona M., Migrenne, Stephanie, Magnan, Christophe, Marley, Anna, Rutter, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354920/
https://ncbi.nlm.nih.gov/pubmed/25830091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.01.006
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