Intra-tumor Heterogeneity in Localized Lung Adenocarcinomas Delineated by Multi-region Sequencing

Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intra-tumor heterogeneity (ITH). ITH in lung cancers has not been well studied. We applied multi-region whole exome sequencing (WES) on 11 localized lung adenocarcinomas. All tumors show...

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Détails bibliographiques
Publié dans:Science
Auteurs principaux: Zhang, Jianjun, Fujimoto, Junya, Zhang, Jianhua, Wedge, David C., Song, Xingzhi, Zhang, Jiexin, Seth, Sahil, Chow, Chi-Wan, Cao, Yu, Gumbs, Curtis, Gold, Kathryn A., Kalhor, Neda, Little, Latasha, Mahadeshwar, Harshad, Moran, Cesar, Protopopov, Alexei, Sun, Huandong, Tang, Jiabin, Wu, Xifeng, Ye, Yuanqing, William, William N., Lee, Jack J., Heymach, John V., Hong, Waun Ki, Swisher, Stephen, Wistuba, Ignacio I., Futreal, P. Andrew
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354858/
https://ncbi.nlm.nih.gov/pubmed/25301631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1256930
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