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RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis
Myeloproliferative neoplasms (MPNs) frequently have an activating mutation in the gene encoding Janus kinase 2 (JAK2). Thus, targeting the pathway mediated by JAK and its downstream substrate, signal transducer and activator of transcription (STAT), may yield clinical benefit for patients with MPNs...
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| Vydáno v: | Sci Signal |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4353591/ https://ncbi.nlm.nih.gov/pubmed/25538080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005301 |
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