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RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis

Myeloproliferative neoplasms (MPNs) frequently have an activating mutation in the gene encoding Janus kinase 2 (JAK2). Thus, targeting the pathway mediated by JAK and its downstream substrate, signal transducer and activator of transcription (STAT), may yield clinical benefit for patients with MPNs...

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Detalles Bibliográficos
Publicado en:Sci Signal
Autores principales: Winter, Peter S., Sarosiek, Kristopher A., Lin, Kevin H., Meggendorfer, Manja, Schnittger, Susanne, Letai, Anthony, Wood, Kris C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353591/
https://ncbi.nlm.nih.gov/pubmed/25538080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005301
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