HuR post-transcriptionally regulates WEE1: Implications for the DNA damage response in pancreatic cancer cells

HuR (ELAV1), an RNA binding protein abundant in cancer cells, primarily resides in the nucleus, but under specific stress (e.g., gemcitabine), HuR translocates to the cytoplasm where it tightly modulates the expression of mRNA survival cargo. Herein, we demonstrate for the first time that stressing...

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Vydáno v:Cancer Res
Hlavní autoři: Lal, Shruti, Burkhart, Richard A., Beeharry, Neil, Bhattacharjee, Vikram, Londin, Eric R., Cozzitorto, Joseph A., Romeo, Carmella, Jimbo, Masaya, Norris, Zoë A., Yeo, Charles J., Sawicki, Janet A., Winter, Jordan M., Rigoutsos, Isidore, Yen, Timothy J., Brody, Jonathan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353573/
https://ncbi.nlm.nih.gov/pubmed/24536047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1915
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