Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein–Protein Interactions

[Image: see text] Protein–protein interactions encompass large surface areas, but often a handful of key residues dominate the binding energy landscape. Rationally designed small molecule scaffolds that reproduce the relative positioning and disposition of important binding residues, termed “hotspot...

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Udgivet i:J Am Chem Soc
Main Authors: Lao, Brooke Bullock, Drew, Kevin, Guarracino, Danielle A., Brewer, Thomas F., Heindel, Daniel W., Bonneau, Richard, Arora, Paramjit S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353027/
https://ncbi.nlm.nih.gov/pubmed/24972345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja502310r
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