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Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein–Protein Interactions
[Image: see text] Protein–protein interactions encompass large surface areas, but often a handful of key residues dominate the binding energy landscape. Rationally designed small molecule scaffolds that reproduce the relative positioning and disposition of important binding residues, termed “hotspot...
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| Pubblicato in: | J Am Chem Soc |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2014
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4353027/ https://ncbi.nlm.nih.gov/pubmed/24972345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja502310r |
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