Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.

T lymphocytes have been implicated in the onset of many autoimmune diseases; however, the mechanisms underlying T-cell activation toward self antigens are poorly understood. To study whether T-lymphocyte costimulation can overcome the immunologic unresponsiveness observed in an in vivo model, we hav...

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Autores principales: Harlan, D M, Hengartner, H, Huang, M L, Kang, Y H, Abe, R, Moreadith, R W, Pircher, H, Gray, G S, Ohashi, P S, Freeman, G J
Formato: Artigo
Lenguaje:Inglês
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC43530/
https://ncbi.nlm.nih.gov/pubmed/7512724
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