Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.

A synthetic peptide corresponding to an immunodominant epitope of lymphocytic choriomeningitis virus glycoprotein (LCMV GP) was used to prime or to tolerize CD8+ T cells in vivo, dependent on mode of immunization. Peptide-specific tolerance was then examined in transgenic mice expressing LCMV GP in...

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Autores principales: Aichele, P, Kyburz, D, Ohashi, P S, Odermatt, B, Zinkernagel, R M, Hengartner, H, Pircher, H
Formato: Artigo
Lenguaje:Inglês
Publicado: 1994
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC42965/
https://ncbi.nlm.nih.gov/pubmed/8290546
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