Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

Subunit vaccines comprised of glycoprotein D (gD-2) failed to prevent HSV-2 highlighting need for novel strategies. To test the hypothesis that deletion of gD-2 unmasks protective antigens, we evaluated the efficacy and safety of an HSV-2 virus deleted in gD-2 and complemented allowing a single roun...

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Vydáno v:eLife
Hlavní autoři: Petro, Christopher, González, Pablo A, Cheshenko, Natalia, Jandl, Thomas, Khajoueinejad, Nazanin, Bénard, Angèle, Sengupta, Mayami, Herold, Betsy C, Jacobs, William R
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2015
Témata:
Microbiology and Infectious Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352706/
https://ncbi.nlm.nih.gov/pubmed/25756612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06054
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