The Vaginal Acquisition and Dissemination of HIV-1 Infection in a Novel Transgenic Mouse Model Is Facilitated by Coinfection with Herpes Simplex Virus 2 and Is Inhibited by Microbicide Treatment

Epidemiological studies have demonstrated that herpes simplex virus 2 (HSV-2) infection significantly increases the risk of HIV-1 acquisition, thereby contributing to the expanding HIV-1 epidemic. To investigate whether HSV-2 infection directly facilitates mucosal HIV-1 acquisition, we used our tran...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Seay, Kieran, Khajoueinejad, Nazanin, Zheng, Jian Hua, Kiser, Patrick, Ochsenbauer, Christina, Kappes, John C., Herold, Betsy, Goldstein, Harris
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542360/
https://ncbi.nlm.nih.gov/pubmed/26157126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01326-15
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