The Apoptotic Mechanism of Action of the Sphingosine Kinase 1 Selective Inhibitor SKI-178 in Human Acute Myeloid Leukemia Cell Lines

We previously developed SKI-178 (N′-[(1E)-1-(3,4-dimethoxyphenyl)ethylidene]-3-(4-methoxxyphenyl)-1H-pyrazole-5-carbohydrazide) as a novel sphingosine kinase-1 (SphK1) selective inhibitor and, herein, sought to determine the mechanism-of-action of SKI-178–induced cell death. Using human acute myeloi...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Dick, Taryn E., Hengst, Jeremy A., Fox, Todd E., Colledge, Ashley L., Kale, Vijay P., Sung, Shen-Shu, Sharma, Arun, Amin, Shantu, Loughran, Thomas P., Kester, Mark, Wang, Hong-Gang, Yun, Jong K.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2015
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352591/
https://ncbi.nlm.nih.gov/pubmed/25563902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.219659
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