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Role of αA-crystallin-derived αA66-80 peptide in guinea pig lens crystallin aggregation and insolubilization

Earlier we reported that low molecular weight (LMW) peptides accumulate in aging human lens tissue and that among the LMW peptides, the chaperone inhibitor peptide αA66-80, derived from α-crystallin protein, is one of the predominant peptides. We showed that in vitro αA66-80 induces protein aggregat...

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Dades bibliogràfiques
Publicat a:Exp Eye Res
Autors principals: Raju, Murugesan, Mooney, Brian P., Thakkar, Kavi M., Giblin, Frank J., Schey, Kevin L., Sharma, K. Krishna
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352376/
https://ncbi.nlm.nih.gov/pubmed/25639202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2015.01.024
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