Independent recruitment of Igh alleles in V(D)J recombination

How the vast majority of B cells express only one of the two alleles at their immunoglobulin loci remains a biological puzzle. Here, in mice reconstituted with a single haematopoietic stem cell, we demonstrate that each of the two immunoglobulin heavy chain (Igh) alleles has a similar probability to...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Alves-Pereira, Clara F., de Freitas, Raquel, Lopes, Telma, Gardner, Rui, Marta, Filipa, Vieira, Paulo, Barreto, Vasco M.
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351640/
https://ncbi.nlm.nih.gov/pubmed/25517887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6623
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