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Interleukin-1β and tumor necrosis factor-α increase stiffness and impair contractile function of articular chondrocytes
Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are major proinflammatory cytokines involved in osteoarthritis (OA). These cytokines disturb chondrocyte metabolism by suppressing the synthesis of extracellular matrix proteins and stimulating the release of catabolic proteases, but little...
Gardado en:
| Publicado en: | Acta Biochim Biophys Sin (Shanghai) |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351355/ https://ncbi.nlm.nih.gov/pubmed/25520178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abbs/gmu116 |
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