Interleukin-1β and tumor necrosis factor-α increase stiffness and impair contractile function of articular chondrocytes

Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are major proinflammatory cytokines involved in osteoarthritis (OA). These cytokines disturb chondrocyte metabolism by suppressing the synthesis of extracellular matrix proteins and stimulating the release of catabolic proteases, but little...

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Foilsithe in:Acta Biochim Biophys Sin (Shanghai)
Main Authors: Chen, Cheng, Xie, Jing, Rajappa, Ravikumar, Deng, Linhong, Fredberg, Jeffrey, Yang, Liu
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2015
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Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351355/
https://ncbi.nlm.nih.gov/pubmed/25520178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abbs/gmu116
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