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Interleukin-1β and tumor necrosis factor-α increase stiffness and impair contractile function of articular chondrocytes
Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are major proinflammatory cytokines involved in osteoarthritis (OA). These cytokines disturb chondrocyte metabolism by suppressing the synthesis of extracellular matrix proteins and stimulating the release of catabolic proteases, but little...
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| Publicado no: | Acta Biochim Biophys Sin (Shanghai) |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351355/ https://ncbi.nlm.nih.gov/pubmed/25520178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/abbs/gmu116 |
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