Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity

Src homology 2 (SH2) domains are modular protein structures that bind phosphotyrosine (pY)-containing polypeptides and regulate cellular functions through protein-protein interactions. Proteomics analysis showed that the SH2 domains of Src family kinases are themselves tyrosine phosphorylated in blo...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cell Proteomics
Hauptverfasser: Jin, Lily L., Wybenga-Groot, Leanne E., Tong, Jiefei, Taylor, Paul, Minden, Mark D., Trudel, Suzanne, McGlade, C. Jane, Moran, Michael F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349988/
https://ncbi.nlm.nih.gov/pubmed/25587033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.044404
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