An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the accumulation of senescent cells is thought to drive age-related pathology through a senescence-associated secretory phenotype (SASP), the function of which is unclear. To understand the physiological role(s) o...

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Détails bibliographiques
Publié dans:Dev Cell
Auteurs principaux: Demaria, Marco, Ohtani, Naoko, Youssef, Sameh A., Rodier, Francis, Toussaint, Wendy, Mitchell, James R., Laberge, Remi-Martin, Vijg, Jan, Van Steeg, Harry, Dollé, Martijn E.T., Hoeijmakers, Jan H.J., de Bruin, Alain, Hara, Eiji, Campisi, Judith
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349629/
https://ncbi.nlm.nih.gov/pubmed/25499914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.11.012
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