Endogenous Interferon-β-Inducible Gene Expression and Interferon-β-Treatment Are Associated with Reduced T Cell Responses to Myelin Basic Protein in Multiple Sclerosis

Autoreactive CD4(+) T-cells are considered to play a major role in the pathogenesis of multiple sclerosis. In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, exogenous and endogenous type I interferons restrict disease severity. Recombinant interferon-β is used for...

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Veröffentlicht in:PLoS One
Hauptverfasser: Börnsen, Lars, Romme Christensen, Jeppe, Ratzer, Rikke, Hedegaard, Chris, Søndergaard, Helle B., Krakauer, Martin, Hesse, Dan, Nielsen, Claus H., Sorensen, Per S., Sellebjerg, Finn
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349448/
https://ncbi.nlm.nih.gov/pubmed/25738751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118830
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