Effect of Natalizumab on Circulating CD4(+) T-Cells in Multiple Sclerosis

In multiple sclerosis (MS), treatment with the monoclonal antibody natalizumab effectively reduces the formation of acute lesions in the central nervous system (CNS). Natalizumab binds the integrin very late antigen (VLA)-4, expressed on the surface of immune cells, and inhibits VLA-4 dependent tran...

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Detalhes bibliográficos
Main Authors: Börnsen, Lars, Christensen, Jeppe Romme, Ratzer, Rikke, Oturai, Annette Bang, Sørensen, Per Soelberg, Søndergaard, Helle Bach, Sellebjerg, Finn
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511477/
https://ncbi.nlm.nih.gov/pubmed/23226199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047578
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