Effect of Natalizumab on Circulating CD4(+) T-Cells in Multiple Sclerosis

In multiple sclerosis (MS), treatment with the monoclonal antibody natalizumab effectively reduces the formation of acute lesions in the central nervous system (CNS). Natalizumab binds the integrin very late antigen (VLA)-4, expressed on the surface of immune cells, and inhibits VLA-4 dependent tran...

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Bibliographische Detailangaben
Hauptverfasser: Börnsen, Lars, Christensen, Jeppe Romme, Ratzer, Rikke, Oturai, Annette Bang, Sørensen, Per Soelberg, Søndergaard, Helle Bach, Sellebjerg, Finn
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511477/
https://ncbi.nlm.nih.gov/pubmed/23226199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047578
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