p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage

The inhibitory role of p53 in DNA double-strand break (DSB) repair seems contradictory to its tumor-suppressing property. The p53 isoform Δ113p53/Δ133p53 is a p53 target gene that antagonizes p53 apoptotic activity. However, information on its functions in DNA damage repair is lacking. Here we repor...

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Vydáno v:Cell Res
Hlavní autoři: Gong, Lu, Gong, Hongjian, Pan, Xiao, Chang, Changqing, Ou, Zhao, Ye, Shengfan, Yin, Le, Yang, Lina, Tao, Ting, Zhang, Zhenhai, Liu, Cong, Lane, David P, Peng, Jinrong, Chen, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349251/
https://ncbi.nlm.nih.gov/pubmed/25698579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.22
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