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Identification of 2,4-diamino-6,7-dimethoxyquinoline derivatives as G9a inhibitors
G9a is a histone lysine methyltransferase (HKMT) involved in epigenetic regulation via the installation of histone methylation marks. 6,7-Dimethoxyquinazoline analogues, such as BIX-01294, are established as potent, substrate competitive inhibitors of G9a. With an objective to identify novel chemoty...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4349132/ https://ncbi.nlm.nih.gov/pubmed/25750706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4md00274a |
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