LYN-activating mutations mediate antiestrogen resistance in estrogen receptor–positive breast cancer

Estrogen receptor–positive (ER(+)) breast cancers adapt to hormone deprivation and become resistant to antiestrogen therapy. Here, we performed deep sequencing on ER(+) tumors that remained highly proliferative after treatment with the aromatase inhibitor letrozole and identified a D189Y mutation in...

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Vydáno v:J Clin Invest
Hlavní autoři: Schwarz, Luis J., Fox, Emily M., Balko, Justin M., Garrett, Joan T., Kuba, María Gabriela, Estrada, Mónica Valeria, González-Angulo, Ana María, Mills, Gordon B., Red-Brewer, Monica, Mayer, Ingrid A., Abramson, Vandana, Rizzo, Monica, Kelley, Mark C., Meszoely, Ingrid M., Arteaga, Carlos L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348968/
https://ncbi.nlm.nih.gov/pubmed/25401474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72573
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