Structural and Biological Evaluation of a Novel Series of Benzimidazole Inhibitors of Francisella tularensis Enoyl-ACP Reductase (FabI)

Francisella tularensis, the causative agent of tularemia, presents a significant biological threat and is a Category A priority pathogen due to its potential for weaponization. The bacterial FASII pathway is a viable target for the development of novel antibacterial agents treating Gram-negative inf...

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Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Mehboob, Shahila, Song, Jinhua, Hevener, Kirk E, Su, Pin-Chih, Boci, Teuta, Brubaker, Libby, Truong, Lena, Mistry, Tina, Deng, Jiangping, Cook, James L, Santarsiero, Bernard D, Ghosh, Arun K, Johnson, Michael E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348352/
https://ncbi.nlm.nih.gov/pubmed/25677657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.01.048
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