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Porphyromonas gingivalis Gingipains Selectively Reduce CD14 Expression, Leading to Macrophage Hyporesponsiveness to Bacterial Infection

Cysteine proteases (gingipains) from Porphyromonas gingivalis are key virulence factors in chronic periodontitis. Innate immune receptors CD14, Toll-like receptor (TLR) 2 and TLR4 are important in P. gingivalis recognition. We examined the ability of gingipains to cleave CD14, TLR2 and TLR4, and the...

詳細記述

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書誌詳細
出版年:J Innate Immun
主要な著者: Wilensky, Asaf, Tzach-Nahman, Rinat, Potempa, Jan, Shapira, Lior, Nussbaum, Gabriel
フォーマット: Artigo
言語:Inglês
出版事項: S. Karger AG 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348206/
https://ncbi.nlm.nih.gov/pubmed/25228314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000365970
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