Porphyromonas gingivalis Gingipains Selectively Reduce CD14 Expression, Leading to Macrophage Hyporesponsiveness to Bacterial Infection

Cysteine proteases (gingipains) from Porphyromonas gingivalis are key virulence factors in chronic periodontitis. Innate immune receptors CD14, Toll-like receptor (TLR) 2 and TLR4 are important in P. gingivalis recognition. We examined the ability of gingipains to cleave CD14, TLR2 and TLR4, and the...

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Detaylı Bibliyografya
Yayımlandı:J Innate Immun
Asıl Yazarlar: Wilensky, Asaf, Tzach-Nahman, Rinat, Potempa, Jan, Shapira, Lior, Nussbaum, Gabriel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: S. Karger AG 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348206/
https://ncbi.nlm.nih.gov/pubmed/25228314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000365970
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