Porphyromonas gingivalis Gingipains Selectively Reduce CD14 Expression, Leading to Macrophage Hyporesponsiveness to Bacterial Infection

Cysteine proteases (gingipains) from Porphyromonas gingivalis are key virulence factors in chronic periodontitis. Innate immune receptors CD14, Toll-like receptor (TLR) 2 and TLR4 are important in P. gingivalis recognition. We examined the ability of gingipains to cleave CD14, TLR2 and TLR4, and the...

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Bibliografiska uppgifter
I publikationen:J Innate Immun
Huvudupphovsmän: Wilensky, Asaf, Tzach-Nahman, Rinat, Potempa, Jan, Shapira, Lior, Nussbaum, Gabriel
Materialtyp: Artigo
Språk:Inglês
Publicerad: S. Karger AG 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348206/
https://ncbi.nlm.nih.gov/pubmed/25228314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000365970
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