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Axonal and Schwann Cell BACE1 Is Equally Required for Remyelination of Peripheral Nerves

Inhibition of β-site APP cleaving enzyme 1 (BACE1) is being pursued as a therapeutic target for treating patients with Alzheimer's disease because BACE1 is the sole β-secretase for generating β-amyloid peptide. Knowledge regarding the other cellular functions of BACE1 is therefore critical for...

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Publicado en:J Neurosci
Autores principales: Hu, Xiangyou, Hu, Jinxuan, Dai, Lu, Trapp, Bruce, Yan, Riqiang
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348183/
https://ncbi.nlm.nih.gov/pubmed/25740511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5207-14.2015
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