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BACE1 regulates the proliferation and cellular functions of Schwann cells

BACE1 is an indispensable enzyme for generating β-amyloid peptides, which are excessively accumulated in brains of Alzheimer’s patients. However, BACE1 is also required for proper myelination of peripheral nerves, as BACE1-null mice display hypomyelination. In order to determine the precise effects...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Glia
Hauptverfasser: Hu, Xiangyou, Hou, Hailong, Bastian, Chinthasagar, He, Wanxia, Qiu, Shupeng, Ge, Yingying, Yin, Xinhua, Kidd, Grahame J., Brunet, Sylvain, Trapp, Bruce D., Baltan, Selva, Yan, Riqiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357169/
https://ncbi.nlm.nih.gov/pubmed/28191691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23122
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